New research led by a team of scientists in Canada has demonstrated how a high-fat diet can disrupt levels of an intestinal immune cell known to help regulate microbial populations in the gut. The study describes how low levels of this molecule result in increased growth of harmful gut bacteria, leading to inflammation and insulin resistance.

    Immunoglobulin A (IgA) is a major immune molecule produced by mucosal secretions in the gut. This new study started off with the hypothesis that IgA could be the crucial mechanistic link connecting the gut microbiome with both inflammation and blood sugar levels related to type 2 diabetes.