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Two-stage diagnostic process detects Alzheimer’s years before symptoms appear PDF Imprimare
Luni, 06 Mai 2019 18:44
                      Klaus Gerwert (left) and Andreas Nabers suggest this new two-step diagnostic process will help Alzheimer's clinical...

Klaus Gerwert (left) and Andreas Nabers suggest this new two-step diagnostic process will help Alzheimer's clinical trials recruit candidates at early stages in the disease progression, before clinical symptoms appear(Credit: RUB, Marquard)

    A new two-step diagnostic process is claiming to confidently detect Alzheimer's disease nearly a decade before clinical symptoms appear. It's hoped that the method, which involves the measurement of both amyloid and tau proteins in blood and cerebrospinal fluid, will improve the results of clinical trials by helping better identify patients at the earliest stages of the disease.

    The general hypothesis explaining the cause of Alzheimer's disease is that the aggregation of toxic amyloid and tau proteins in the brain results in neurodegenerative damage associated with cognitive decline. However a near-constant parade of clinical trial failures targeted at reducing the build-up of those toxic proteins have led to critical reconsiderations from many Alzheimer's researchers. While some scientists are investigating dramatically different hypotheses, others are suggesting the original protein hypothesis could still be correct, but simply needs to be targeted before any symptoms appear.

 

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