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Hidroxiclorochină PDF Imprimare
Sanatate
Duminică, 05 Aprilie 2020 16:49
                            Hydroxychloroquine.png

   Hidroxiclorochina, un derivat de 4-aminochinolină, este un medicament antimalarica cărui acțiune schizontocidă rapidă se asociază cu activitatea gametocidă și este, totodată, un antireumatic cu mecanism de absorbție întârziată.
 

Mod de acțiune

Hidroxiclorochina are mai multe proprietăți farmacologice:

  • interacțiuni cu grupări sulfhidril SH
  • modularea activității unor enzime (între care fosfolipaza, NADH-citocrom-C-reductaza, colinesteraze, proteaze și hidrolaze)
  • stabilizarea membranelor lizozomale
  • inhibarea formării prostaglandinelor, a funcției chemotactice și fagocitice a polimorfonuclearelor;
  • posibila interferare a producerii de interleukină-1 de către monocite și inhibarea eliberării de anion superoxid de către neutrofile. Concentrarea în veziculele acide intracelulare și creșterea consecutivă a pH-ului acestora poate explica atât efectele antiprotozoarice, cât și pe cele antireumatice.Hidroxiclorochina se absoarbe rapid după administrare orală. Biodisponibilitatea medie este aproximativ 74%. Este larg distribuită în organism și se acumulează în celula eritrocitară și în țesutul hepatic, pulmonar, renal și ocular. Este biotransformată parțial în ficat la metabolitul etilat activ și este eliminată principal pe cale renală, în proporție de 23 – 25% în formă nemodificată, dar și pe cale biliară. Eliminarea este lentă, semiviața de eliminare finală fiind aproximativ 50 de zile (sânge integral) sau 32 de zile (plasmă). Hidroxiclorochina traversează bariera placentară și, probabil, asemănător clorochinei, se elimină în laptele matern.
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Coronavirus disease 2019 (COVID-19)Situation Report –45 PDF Imprimare
Sanatate
Vineri, 06 Martie 2020 09:31

             Organizatia  Mondiala  a Sanatatii


         

                       Image result for bolnav


                   HIGHLIGHTS
•Five newcountries/territories/areas(Bosnia and Herzegovina, Gibraltar, Hungary, Slovenia, and occupied Palestinian territory) have reported cases of COVID-19 in the past 24 hours.
•In anticipation for an increase in the number of COVID-19 cases, the South-East Asia Region is preparing to roll out rapid response activities by engaging with communities, procuring personal protective equipment (PPE), and ensuring laboratories have the capacity to test for COVID-19 or ship samples to global referral laboratories. More information can be found here.
•The WHO Director-General emphasized the importance of implementing a comprehensiveapproach to mitigate the impact of COVID-19. Educating the population, expanding surveillance, caring for patients, and strengthening preparedness systems are key to interrupting transmission. The WHO Director-General’s remarks can be found here.
•WHO’s initiative called the WHO Network for Information in Epidemics (EPI-WIN) leverages all communications platformsto amplify evidence-based information.EPI-WIN has identified trusted sources and engaged with these “trust chains”. More information can be found in the Subject in Focus
     SITUATION IN NUMBERS 
total and new cases in last 24 hours
Globally 95 333 confirmed (2241 new)
China     80 565 confirmed (143 new)3015 deaths (31 new)
Outside of China14 768 confirmed (2098 new)
85 Countries/territories/ areas (5new)267 deaths (53 new)
WHO RISK ASSESSMENT
China                   Very  High
Regional Level    Very High
Global     Level     Very High
*
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Coronavirus disease 2019 (COVID-19)Situation Report –39 PDF Imprimare
Sanatate
Sâmbătă, 29 Februarie 2020 21:50

                       Data as reported by 10AM CET  -  28 February 2020


                 

who-logo

   S•Five new Member States (Belarus, Lithuania, Netherlands, New Zealand, andNigeria) reported cases of COVID-19 in the past 24 hours
.•WHO has increased the assessment of the risk of spread and risk of impact ofCOVID-19 to very high at the global level. More information can be found here.
•The WHO-China Joint Mission, which was conducted from 16 through 24February, has published its findings. The full report can be found here.
•WHO has updated theguidance on Global Surveillance for human infection withcoronavirus disease (COVID-19).This document includes revised surveillance casedefinitions for COVID-19. It is also accompanied by a revised Case Reporting Form,line listing template, and data dictionary.
•Table 2in this Situation Report,“Countries, territories or areas outside China withreported laboratory-confirmed COVID-19 cases and deaths”, has been simplifiedand now includes transmission classification. See Table 2 footnotes for additionalinformation.
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Coronavirus PDF Imprimare
Sanatate
Vineri, 28 Februarie 2020 19:59

                          

 

OMS a declarat o urgență globală pentru sănătate în legătură cu răspândirea virusului Covid-19.

 

Coronavirus disease 2019 (COVID-19)Situation Report –38

Nine new Member States (Brazil, Denmark, Estonia, Georgia, Greece, Norway, Pakistan, Romania, and NorthMacedonia) reported cases of COVID-19 in the past 24 hours. •WHO and the World Tourism Organization released a joint statement regarding responsibility and coordination on tourism and COVID-19. For more information, please visit this webpage.•OpenWHO, aweb-based learning platform, has launched the free online courses Introduction to Emerging Respiratory Viruses, Including Novel Coronovirus, in Portugueseand Health and Safety Briefing for Respiratory Diseases –ePROTECT in Frenchtoday. •WHO is utilizing an international network of expert laboratories to provide support in the detection of the COVID-19 virus globally.For more information, please see the Subject in Focus below
SITUATION IN NUMBERS total and new cases in last 24 hours
Globally 82 294confirmed (1185new)
China78 630confirmed (439new)2747deaths (29new)
Outside of China3664confirmed (746new)46 countries (9 new)57 deaths (13 new)WHO RISK ASSESSMENT
China        Very High
Regional   LevelHigh
Global      LevelHigh

 

 

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Coronavirus disease - Data as reported by 10AM CET24 February 2020* PDF Imprimare
Sanatate
Marţi, 25 Februarie 2020 00:23

 

       

who-logo

 

        SITUATION IN NUMBERS total and new cases in last 24 hours

Globally 79 331 confirmed (715new)

China    77 262 confirmed (415 new  )2595 deaths (150 new)

Outside of China  2069  confirmed (300new)

29 countries   (1 new)   23deaths (6new)


       WHO RISK ASSESSMENT

China          Very   High

Regional     Level  High

Global         Level High

 

   HIGHLIGHTS

•One new Member State (Kuwait)reported cases of COVID-19 in the past 24 hours.

•Since the emergence of COVID-19 we have seen instances of public stigmatization among specific populations, and the rise of harmful stereotypes. Stigmatization could potentially contribute to more severe health problems, ongoing transmission, and difficulties controlling infectious diseases during an epidemic.Please see the Subject in Focus section for more information on how to counter stigmatizing attitudes.

 

SUBJECT IN FOCUS:Risk Communications to Address StigmaStigma occurs when people negatively associate an infectious disease, such as COVID-19, with a specific population. In the case of COVID-19, there are an increasing number of reports of public stigmatization against people from areas affected by the epidemic. Unfortunately, this means that people are being labelled, stereotyped, separated, and/or experience loss of status and discrimination because of apotentialnegative affiliation with the disease.Given that COVID-19 is a new disease, it is understandable that its emergence and spread cause confusion,anxiety and fear among the general public. These factors can give rise to harmful stereotypes.

Stigma can:

•Drive people to hide the illness to avoid discrimination •Prevent people from seeking health care immediately •Discourage them from adopting healthy behaviours Such barriers could potentially contribute to more severe health problems, ongoing transmission, and difficulties controlling infectious diseases during an infectious disease outbreak.

The International Federation of Red Cross and Red Crescent Societies (IFRC), UNICEF and the WHO are developing community-basedguides and global campaigns to thwart the effects of stigma on people and the COVID-19 response.

Do your part.Governments, citizens, media, key influencers and communities have an important role to play in preventing and stopping stigma. We all need tobe intentional and thoughtful when communicating on social media and other communication platforms, showing supportive behaviors around COVID-19.Here are some examples and tips on possible actions to counter stigmatizing attitudes: •Spreading the facts: Stigma can be heightened by insufficient knowledge about how the new coronavirus disease (COVID-19) is transmitted and treated, and how to prevent infection. •Engaging social influencerssuch as religious leaders on prompting reflection about people who are stigmatized and how to support them, or respected celebrities to amplify messages that reduce stigma. •Amplify the voices, stories and images of local people who have experienced COVID-19 and have recovered or who have supported a loved one through recovery to emphasise that most people do recover from COVID-19.•Make sure you portray different ethnic groups.

Materials should show diverse communities that are being affected, and show communities working together to prevent the spread of COVID-19.

•Balanced reporting.Media reporting should be balanced and contextualised, disseminating evidence-based information and helping combat rumour and misinformation that could lead to stigmatisation.•Link up.There are a number ofinitiatives to address stigma and stereotyping. It is key to link up to these activities to create a movement and a positive environment that shows care and empathy for all .

*

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